Preclinical Services - Proliferation and Cytotoxicity Assays

Proliferation and Cytotoxicity Assays can be used in conjunction with high throughput screening results to evaluate compounds that enhance proliferation or initiate toxicity in cell populations.  With the aid of our testing, clients can make better informed decisions regarding target compounds.
  • Progenitor assays
  • Myeloid and Erythroid progenitor (CFU-E, BFU-E, CFU-GM and CFU-GEMM)
  • Megakaryocyte progenitors (CFU-Mk)
  • Mesenchymal Progenitors (CFU-F)
  • Elimination of myelo-suppressing compounds early in the drug discovery process.
  • Toxicity testing of lead compounds prior to Phase I clinical trials (determination of MTDs). This assay allows the examination of various primary cell lineages.
  • Identification of growth factor mimetics.
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